Prof. Linda Wilson-Pauwels and Prof. Dave Mazierski
EDIT: Jan 19, 2011 | Crossed-off items have been incorporated into latest version of 2D animatic. The rest will be incorporated into the 3D animatic.
Comments on 2D Animatic
Title
- Change "burden" to something that relates back to pain, such as "patient's struggle", "implications on pain", etc.
Segment 01, Scene 01
- Start talk when title screen is on to move things along faster.
- Woman: Draw an older woman
- Joint: Rotate less when zooming into joint
Segment 02, Scene 01
- Make sure pain signal crosses over to other side of brain! * Crosses at level of spinal cord and goes to contralateral side --> Ask whether need to label "spinothalamic tract
- Label green particles "inflammatory mediators"
- Also list mediators along with narration
- Give blood vessel a hint of red
Segment 02, Scene 02
- Rotate membrane surface to match orientation of nociceptor (at cellular level)
Segment 02, Scene 03
Retrograde transport
- Show schematic of cell body within the dorsal root ganglion before zooming in to reinforce that the DRG contains many cell bodies
- Need to label "retrograde transport"
- Colour of NGF-TrkA - make a mixture of orange and pink particles
- Check timing before introducing "pronociceptive molecules"
Pain mediators
- "These pain mediators activate second-order neurons in the dorsal horn, firing signals to the CNS"
- The signal has to cross over to the contralateral side at the spinal cord level
Ion channels
- add "pre-assembled ion channels" to narration to clarify that the channels are manufactured in the cell body, and transported in vesicles down the axon
- Show tiny purple channels popping out of nociceptor membrane surface
- Use the term "anterograde" in narration and label "anterograde transport"
Segment 03, Scene 02
- Need to contextualize where pathway is happening by adding a membrane
- Or consider removing that part altogether, and just jump from patient with pill to pathways
- Check retrograde/anterograde transport wording
Comments on 2D Animatic
Title
- Change "burden" to something that relates back to pain, such as "patient's struggle", "implications on pain", etc.
Segment 01, Scene 01
- Start talk when title screen is on to move things along faster.
- Woman: Draw an older woman
- Joint: Rotate less when zooming into joint
Segment 02, Scene 01
- Give blood vessel a hint of red
Segment 02, Scene 02
- Rotate membrane surface to match orientation of nociceptor (at cellular level)
Segment 02, Scene 03
Retrograde transport
- Show schematic of cell body within the dorsal root ganglion before zooming in to reinforce that the DRG contains many cell bodies
- Need to label "retrograde transport"
- Colour of NGF-TrkA - make a mixture of orange and pink particles
Pain mediators
- "These pain mediators activate second-order neurons in the dorsal horn, firing signals to the CNS"
Ion channels
- add "pre-assembled ion channels" to narration to clarify that the channels are manufactured in the cell body, and transported in vesicles down the axon
- Show tiny purple channels popping out of nociceptor membrane surface
- Use the term "anterograde" in narration and label "anterograde transport"
Segment 03, Scene 02
- Need to contextualize where pathway is happening by adding a membrane
- Or consider removing that part altogether, and just jump from patient with pill to pathways
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