Committee Meeting II: 2D animatic

Committee members present: Prof. Michael Corrin

EDIT: Jan 19, 2011 | Crossed-off items have been incorporated into latest version of 2D animatic. The rest will be incorporated into the 3D animatic.

Segment 01, scene 01

- To give the illustration "life", redraw same image several times ("crackle")

- Also can add subtle movements to hands to further indicate pain

- Transition from gross to cellular level: consider using a radiating blur to make it more convincing

Segment 02, scene 01

- When mention "immune cells", should differentiate those cells from the other ones (highlighting, glow, slight change in hue, etc.)

- Add a list of labels for mediators (colour-coded)

- Coordinate timing between visuals and narration better: "recruit more immune cells from the blood" should come before the visuals.

Segment 02, scene 02

- May need to add a title "peripheral sensitization" to set up molecular part, sort of a part 2 to what was discussed at the cellular level

- When talking about signalling pathways, want to zoom out from close shot of the membrane with TrkA-NGF and TRPV1, to show the full signalling pathways (conveyed by arrows, etc.) to really link together what happens at the TrkA-NGF complex with the modifications to TRPV1

- Vesicle formation: To better match the orientation of the cell body shot, go from molecular level to peripheral ending first (show vesicles budding off the membrane). Then go to the cell body shot. "...affects distant sites..."

Segment 02, scene 03

- Consider adding numbers to this shot to really drive the message home - e.g. (1) transport, (2) changes in gene expression, (3) increased pronociceptive molecules

- When the ion channels are moving from the cell body to the periphery, add a zoom-in of the vesicles to show the embedded channels

- "...ultimately, greater pain sensation." - need to cut back to patient in pain...

Segment 03, scene 01

- To link together the end with the beginning, consider including the cascade at the very beginning (at least include the same background pattern in the previous shot with the patient)

Overall considerations:

- Schematic depictions/pulling back may be useful in areas explaining pathways, etc.

- Need to tighten up timing/coordination of visuals and narration (narration should precede visuals)